山东大学-成果详情

标题：Elevated Plasma α-Defensins (HNP1-3) Levels Correlated with IgA1 Glycosylation and Susceptibility to IgA Nephropathy

作者：Qi Y.-Y.; Zhou X.-J.; Cheng F.-J.; Zhang H.

作者机构：[Qi, Y.-Y] Renal Division, Peking University First Hospital, Beijing, 100034, China, Peking University Institute of Nephrology, Beijing, 100034, China 更多

通讯作者：Zhang, H(hongzh@bjmu.edu.cn)

通讯作者地址：[Zhang, H] Renal Division, Peking University First HospitalChina;

来源：Disease Markers

出版年：2016

卷：2016

DOI：10.1155/2016/8123138

摘要：Aim. IgA nephropathy (IgAN) is the most common form of glomerulonephritis. Recent genome-wide association study (GWAS) suggested that DEFA locus (which encodes α-defensins) may play a key role in IgAN. Methods. The levels of α-defensins in 169 IgAN patients and 83 healthy controls were tested by ELISA. Results. We observed that α-defensins human neutrophil peptides 1-3 (HNP1-3) in IgAN patients were elevated compared with healthy controls. The mean levels of α-defensins of 83 healthy controls and 169 IgAN patients were 50 ng/mL and 78.42 ng/mL. When the results were adjusted to the mean levels of α-defensins of IgAN patients, the percentage of individuals with high levels of α-defensins increased in IgAN patients (22.5%) compared to healthy controls (9.6%) (p = 0.013). The elevation of α-defensins in IgAN patients was independent of renal function or neutrophil count, which were major sources of α-defensins in circulation. More importantly, negative correlation was observed between galactose-deficient IgA1and α-defensins. Conclusion. As α-defensin is a lectin-like peptide, we speculated that it might be involved in IgA galactose deficiency. The data implied that patients with IgAN had higher plasma α-defensins levels and high α-defensins correlated with IgA galactose deficiency, further suggesting a pathogenic role of α-defensins in IgAN. © 2016 Yuan-yuan Qi et al.

收录类别：SCOPUS

Scopus被引频次：1

资源类型：期刊论文

原文链接：https://www.scopus.com/inward/record.uri?eid=2-s2.0-84985004027&doi=10.1155%2f2016%2f8123138&partnerID=40&md5=81916420acc0ae6ccc96695fcf335e9c

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