标题：Coumarin-based fluorescent probes for H_2S detection
作者：Li, W.;Sun, W.;Yu, X.;Du, L.;Li, M.
作者机构：[Li, W] Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan Shandong 250012, China;[ Sun, W] Department of Medicinal Che 更多
通讯作者地址：[Li, MY]Shandong Univ, Sch Pharm, Key Lab Chem Biol Nat Prod MOE, Dept Med Chem, Jinan 250012, Shandong, Peoples R China.
来源：Journal of Fluorescence
关键词：Cell imaging;Coumarin;Fluorescent probe;H_2S
摘要：Although hydrogen sulfide (H_2S) has been known as a toxic gas with unpleasant rotten egg smell, the correlation between H_2S and physiological processes has attracted scientists to develop brand new methods to monitor such a gaseous molecule in vitro and in vivo. Herein, we described a couple of coumarin-based fluorescent probes (1a and 1b) that can be activated by reduction of azide to amine in the presence of H_2S. It should be emphasized that probe 1b demonstrated high selectivity and sensitivity for H_2S over other relevant reactive sulfur species in vitro, as well as identified exogenous H_2S in living cells.