标题: [Compound erythromycin sustained release preparation and its in vitro release].
作者: Chen, Hai-xia; Chen, Zhi-peng; Wang, Qi-rong; Liu, Ze-kun; Ma, Quan-long
作者机构:[ Chen, Hai-xia; Chen HX] Department of Pharmacy of the Qilu Hospital of Shandong University, Jinan 250012, China.;[ Chen, Zhi-peng; Chen ZP];[ Wang, 更多
来源: Yao xue xue bao = Acta pharmaceutica Sinica
出版年:2011
卷: 46
期: 11
摘要: Using the weight-average molecular weight 50 000 polylactic acid (PLA) as a carrier, and a certain proportion of erythromycin (EM) and prednisone acetate (PNA) to mixed prepare the compound erythromycin sustained release preparation (sustained-release tablets). Using ultraviolet spectrophotometry and high performance liquid chromatography (HPLC) to detect separately the release amount of EM and PNA in vitro medium. The sustained-release tablets release for about 21 days, the average content of EM is 99.7 mg/table, RSD = 0.82%; and the average content of PNA is 10.03 mg/table, RSD = 0.93%. Within 21 days, the cumulative releases of EM and PNA are 86.1% and 78.3%, respectively. The drug release is steady and slow after 5 days, the burst release phenomenon in early stage is more significant. The results showed that the sustained-release tablet preparation method is feasible, the release performance is good and the clinical efficacy is significant.
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资源类型:期刊论文
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