标题:Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson\'s disease in a Chinese population
作者:Hao,H.;Shao,M.;An,J.;Chen,C.;Feng,X.;Xie,S.;Gu,Z.;Chan,P.;Xu,Y.;Feng,T.;Liang,Z.;Bao,H.;Liu,Y.;Guan,X.;Ye,Q.;Chen,H.;Shen,X.;Che
作者机构:[Hao, H] Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;[ Shao, M] Department of Neurologic 更多
通讯作者地址:[Shao, M] Department of Neurologic Rehabilitation, Rehabilitation Hospital of Sichuan Province, No. 81, Bayi Road, China
来源:Parkinsonism & related disorders
出版年:2014
卷:20
期:10
页码:1041-1045
DOI:10.1016/j.parkreldis.2014.06.021
关键词:COMT;Dyskinesias;MAO-B;Parkinson\'s disease;Wearing-off
摘要:Background: Catechol-O-Methyltransferase (COMT) and Monoamine oxidase B (MAO-B) are the main enzymes that metabolize dopamine in the brain. The polymorphisms of the COMT gene and MAO-B gene are associated with high, intermediate and low levels of activity. This may influence the prevalence of motor complications in Parkinson\'s Disease (PD). Methods: The study enrolled 1087 Chinese PD patients throughout the country. Sanger dideoxynucleotide chain termination methods were used for COMT and MAO-B genotyping. The researchers compared the association between presence of motor complications and COMT and MAO-B gene polymorphisms, both separately and in combination. Results: Comparison of the allele frequencies revealed that COMT (GG) was significantly more common among PD patients who exhibited wearing-off compared to PD patients without wearing-off (. P<0.05). A statistically higher frequency of the MAO-B (AG) genotype in PD patients with dyskinesias was found (. P<0.05). Although these differences were not significant after Bonferroni\'s correction. The combined haplotype of the MAO-B and COMT showed no increase (. p<0.05) in the risk of wearing-off and dyskinesias. Conclusions: Our findings suggest that polymorphisms in COMT and MAO-B may increase the risk of wearing-off and dyskinesias. COMT (GG) genotype may be the risk factor of wearing-off. While MAO-B (AG) genotype may be the risk factor of dyskinesias.
收录类别:SCOPUS
Scopus被引频次:13
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908141172&doi=10.1016%2fj.parkreldis.2014.06.021&partnerID=40&md5=f415b471ad9f080b1ae3b57abc7df276
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