标题:Solubility and Bioavailability Enhancement of Oridonin: A Review
作者:Zhang, Yuanyuan; Wang, Shaohua; Dai, Mengmeng; Nai, Jijuan; Zhu, Liqiao; Sheng, Huagang
作者机构:[Zhang, Yuanyuan; Wang, Shaohua; Dai, Mengmeng; Nai, Jijuan; Zhu, Liqiao; Sheng, Huagang] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, 更多
通讯作者:Zhu, L(zhuliqiao@sdutcm.edu.cn)
通讯作者地址:Zhu, LQ; Sheng, HG (corresponding author), Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Shandong, Peoples R China.
来源:MOLECULES
出版年:2020
卷:25
期:2
DOI:10.3390/molecules25020332
关键词:Oridonin; structural modification; formulations; solubility;; bioavailability; biological activity
摘要:Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb Rabdosia rubescens with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077981413&doi=10.3390%2fmolecules25020332&partnerID=40&md5=1596b2fdde4976911ced2789ab51c68a
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