标题：Effects of climatic factors on plasma lipid levels: A 5-year longitudinal study in a large Chinese population
作者：Zhou, Xiaoming; Lin, Haiyan; Zhang, Shigang; Ren, Jianwei; Wang, Zhe; Zhang, Yun; Wang, Mansen; Zhang, Qunye
作者机构：[Zhou, Xiaoming] Shandong Univ, Shandong Prov Hosp, Div Endocrinol & Metab, Jinan, Peoples R China.; [Zhou, Xiaoming] Shandong Univ, Sch Med, Dept P 更多
通讯作者：Wang, MS;Zhang, QY
通讯作者地址：[Wang, MS]Providence Hlth & Serv, Med Data Res Ctr, Portland, OR USA;[Zhang, QY]Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China.
来源：JOURNAL OF CLINICAL LIPIDOLOGY
关键词：Plasma lipids; Climatic factor; Seasonal variation; Longitudinal; investigation; Temperature
摘要：BACKGROUND: The rules and mechanisms of seasonal changes in plasma lipid levels, which may be related to annual rhythmicity of incidence and mortality of cardiovascular diseases, are still controversial.; OBJECTIVE: The objectives of this study were to study the effects of climatic factors on plasma lipid levels and to preliminarily reveal mechanisms of annual rhythmicity of plasma lipid levels.; METHODS: A longitudinal study was performed using health examination data of 5 consecutive years (47,270 subjects) in Jinan, China. The climate in Jinan is typical temperate continental monsoon climate with huge temperature difference between winter and summer (>30 degrees C).; RESULTS: After considering and adjusting those classical lipid-associated risk factors, such as age, gender, diet, exercise, blood pressure, body weight, change of body weight, body mass index, glycemia, alanine aminotransferase, and creatinine, only air temperature could still significantly affect plasma lipid levels among the main climatic factors (humidity, precipitation, and so forth). For men, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was decreased significantly 0.35, 0.18, and 0.06 mmol/L, respectively, whereas triglyceride was increased significantly 0.12 mmol/L for every 10 degrees C increase in air temperature. For women, total cholesterol and high-density lipoprotein cholesterol were decreased notably 0.73 and 0.32 mmol/L, and low-density lipoprotein cholesterol was increased significantly 0.26 mmol/L for every 10 degrees C increase in air temperature, whereas triglyceride was not significantly affected by air temperature.; CONCLUSION: Air temperature is an independent risk factor for plasma lipid levels besides those classical lipid-associated risk factors. The annual air temperature fluctuations might be an important mechanism of the seasonal changes of lipids. (C) 2016 National Lipid Association. All rights reserved.