标题：Association between DPP4 gene polymorphism and serum lipid levels in Chinese type 2 diabetes individuals
作者：Xing, Xiaomin; Han, Yi; Zhou, Xiaojun; Zhang, Bo; Li, Yan; Wang, Zhongsu; Liao, Lin; Su, Lequn
作者机构：[Xing, Xiaomin; Zhang, Bo] Shandong Univ, Sch Pharm, Jinan, Shandong, Peoples R China.; [Xing, Xiaomin] Qingdao Univ, Affiliated Hosp, Dept Pharm, Q 更多
通讯作者：Liao, L;Su, LQ
通讯作者地址：[Liao, L; Su, LQ]16766 Jingshi Rd, Jinan 250014, Peoples R China.
关键词：DPP4; Polymorphism; Serum lipid levels; Type 2 diabetes
摘要：Objective: The goal of the genetic investigation was to identify the associations of serum lipid levels and DPP-4 variants in Chinese type 2 diabetes patients.; Methods: We detected four variants of the DPP4 gene in. 190 Chinese individuals with type 2 diabetes and tested for an association with dyslipidemia in 82 selected samples. Data including basic information, HbA1c, FPG, serum lipid parameters were collected. Statistical analysis was performed by SPSS 13.0 through ANOVA and chi(2) test.; Results: The genetic polymorphism of rs466/1443, rs3788979, rs7608798 and rs1558957 in Chinese type 2 diabetes were consistent with Hardy-Weinberg equilibrium. The CT genotype of rs4664443 suffered from higher serum TG (P = 0.013), LDL (P = 0.044) and ApoB (P = 0.006) levels, whereas the TT genotype of rs7608798 exhibited a lower serum TG level (P = 0.037). For rs3788979, the serum TG level (P = 0.034) and BMI (P = 0.04) were significantly different among genotypes. Moreover, serum TG and TC levels and BMI showed a positive correlation with the number unfavorable alleles, and individuals with more than two unfavorable alleles had higher TG (P = 0.004), TC (P = 0.011), and BMI (P = 0.044) values.; Conclusions: This is the first study to investigate DPP4 allelic distributions and their association with dyslipidemia in Chinese type 2 diabetes patients, which may have clinical significance. (C) 2016 Elsevier Ltd. All rights reserved.