标题：IL-22 promotes the progression of breast cancer through regulating HOXB-AS5
作者：Jiang Rui; Zhao Chunming; Gao Binbin; Shao Na; Wang Shengxi; Song Wei
作者机构：[Jiang Rui; Gao Binbin; Shao Na; Wang Shengxi; Song Wei] Shandong Univ, Dept Oncol, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China.; [Z 更多
通讯作者地址：[Jiang, R]Shandong Univ, Dept Oncol, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China.
关键词：IL-22; HOXB-AS5; breast cancer; PI3K/AKT/mTOR
摘要：Interleukin-22 (IL-22) is a well-known tumor related inflammatory factor that is associated with variety of cancers. HOXB-AS5, a long non-coding RNA located in HOX gene clusters, has been elevated in breast cancer (BC) tissues. Herein, IL-22 and HOXB-AS5 were upregulated in the serum and tissues of BC patients and were associated with clinical stages. Furthermore, we also investigated the effects of IL-22-HOXB-AS5 pathway on progression of BC, and the results suggested that IL-22 and HOXB-AS5 synergistically promoted MDA-MB-231 cell growth, migration and invasion and activated the PI3K-AKT-mTOR pathway. These findings demonstrated that the IL-22-HOXB-AS5-PI3K/AKT functional axes may serve as potential molecule biomarkers for diagnosis and therapy evaluation or targeted therapeutic strategy in BC.