标题:IL-22 promotes the progression of breast cancer through regulating HOXB-AS5
作者:Jiang Rui; Zhao Chunming; Gao Binbin; Shao Na; Wang Shengxi; Song Wei
作者机构:[Jiang Rui; Gao Binbin; Shao Na; Wang Shengxi; Song Wei] Shandong Univ, Dept Oncol, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China.; [Z 更多
通讯作者:Jiang, R
通讯作者地址:[Jiang, R]Shandong Univ, Dept Oncol, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China.
来源:ONCOTARGET
出版年:2017
卷:8
期:61
页码:103601-103612
DOI:10.18632/oncotarget.22063
关键词:IL-22; HOXB-AS5; breast cancer; PI3K/AKT/mTOR
摘要:Interleukin-22 (IL-22) is a well-known tumor related inflammatory factor that is associated with variety of cancers. HOXB-AS5, a long non-coding RNA located in HOX gene clusters, has been elevated in breast cancer (BC) tissues. Herein, IL-22 and HOXB-AS5 were upregulated in the serum and tissues of BC patients and were associated with clinical stages. Furthermore, we also investigated the effects of IL-22-HOXB-AS5 pathway on progression of BC, and the results suggested that IL-22 and HOXB-AS5 synergistically promoted MDA-MB-231 cell growth, migration and invasion and activated the PI3K-AKT-mTOR pathway. These findings demonstrated that the IL-22-HOXB-AS5-PI3K/AKT functional axes may serve as potential molecule biomarkers for diagnosis and therapy evaluation or targeted therapeutic strategy in BC.
收录类别:SCOPUS;SCIE
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035325288&doi=10.18632%2foncotarget.22063&partnerID=40&md5=dcdb3ded6d9c914e0b1eb72d8cc63e06
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