标题:Isolation and Asymmetric Total Synthesis of Perforanoid A
作者:Lv, Chao; Yan, Xiaohui; Tu, Qian; Di, Yingtong; Yuan, Chunmao; Fang, Xin; Ben-David, Yaacove; Xia, Lei; Gong, Jianxian; Shen, Yuemao 更多
作者机构:[Lv, Chao; Shen, Yuemao] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China.; [Yan, Xiaohui; Di, Yingtong; Fang, Xin; Hao, X 更多
通讯作者:Shen, Yuemao
通讯作者地址:[Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China;[Hao, XJ]Chinese Acad Sci, State Key Lab Phytochem & Plant Resour 更多
来源:ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
出版年:2016
卷:55
期:26
页码:7539-7543
DOI:10.1002/anie.201602783
关键词:asymmetric synthesis; cytotoxicity; limonoids; Pauson-Khand reaction;; total synthesis
摘要:A novel limonoid, perforanoid A, was isolated, and an asymmetric total synthesis was achieved in 10 steps. The key steps are chiral tertiary aminonaphthol mediated enantioselective alkenylation of an aldehyde to an allylic alcohol, Pd-catalyzed coupling of the allylic alcohol with vinyl ether to form the gamma-lactone ring, and cyclopentenone ring formation through a Rh-catalyzed Pauson-Khand reaction. Preliminary studies show that perforanoid A is cytotoxic towards HEL, K562, and CB3 tumor cell lines.
收录类别:EI;SCOPUS;SCIE
WOS核心被引频次:20
Scopus被引频次:20
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969749907&doi=10.1002%2fanie.201602783&partnerID=40&md5=fbfbe42692d9f241fadd09ba92956a9d
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