标题：Administration of embryonic stem cells generates effective antitumor immunity in mice with minor and heavy tumor load
作者机构：[Dong, W] Department of Oncology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250012, China;[ Du, J] Department of Thora 更多
通讯作者地址：[Liu, Q]Shandong Univ, Shandong Prov Hosp, Dept Oncol, 324 Jingwu Rd, Jinan 250012, Peoples R China.
来源：Cancer Immunology and Immunotherapy: Other Biological Response Modifications
关键词：Antitumor immunity;Cancer stem cells;Cancer vaccine;Embryonic stem cells;Immunotherapy
摘要：The history of immunizing animals with fetal tissues to generate an antitumor response dates back a century ago. Subsequent reports supported the idea that vaccination with embryonic materials could generate cancer-specific immunity and protect animals from transplan-table and chemically induced tumors. In our study, we found C57 BL/6 mice vaccinated with embryonic stem cells (ESCs) received obvious antitumor immunity, which protected them from the formation and development of lung cancer. Furthermore, we investigated the antitumor effects of administration of ESCs in mice with minor and/or heavy tumor load. The tumor growth was monitored, the proliferation of lymphocytes and secretion of cytokines were examined, and finally the tissue sections were approached by immunohistochemical and apoptosis staining. The results suggested that mice injected with ESCs received obvious tumor inhibition and retardation due to signiicant lymphocyte proliferation and cytokine secretion, which help to rebuild the host\'s immunity against cancer to some extent and comprise the main part of antitumor immunity. Moreover, mice with minor tumor load received stronger antitumor efect compared with mice with heavy tumor load, may be due to relatively intact immune system. Thus, besides their function as prophylactic vaccines, administration of ESCs could be a potential treatment for cancer, which obviously prevent and control the proliferation and development of malignant tumors.