标题:The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints
作者:Zhang, Weifang; Li, Jing; Kanginakudru, Sriramana; Zhao, Weiming; Yu, Xiuping; Chen, Jason J.
作者机构:[Zhang, Weifang; Li, Jing; Zhao, Weiming; Yu, Xiuping] Shandong Univ, Sch Med, Dept Microbiol, Jinan 250100, Shandong, Peoples R China.; [Zhang, Wei 更多
通讯作者:Yu, XP
通讯作者地址:[Yu, XP]Shandong Univ, Sch Med, Dept Microbiol, Jinan 250100, Shandong, Peoples R China.
来源:VIROLOGY
出版年:2010
卷:397
期:1
页码:139-144
DOI:10.1016/j.virol.2009.10.051
关键词:HPV-58; E7; Checkpoint; Rb; p130; Cdk2; p53; p21
摘要:HPV type 58 (HPV-58) is the third most common HPV type in cervical cancer from Eastern Asia, yet little is known about how it promotes carcinogenesis. In this study, we demonstrate that HPV-58 E7 significantly promoted the proliferation and extended the lifespan of primary human keratinocytes (PHKs). HPV-58 E7 abrogated the G1 and the postmitotic checkpoints, although less efficiently than HPV-16 ET Consistent with these observations, HPV-58 E7 down-regulated the cellular tumor suppressor pRb to a lesser extent than HPV-16 ET Similar to HPV-16 E7 expressing PHKs, Cdk2 remained active in HPV-58 E7 expressing PHKs despite the presence of elevated levels of p53 and p21. interestingly, HPV-58 E7 down-regulated p130 more efficiently than HPV-16 ET Our study demonstrates a correlation between the ability of down-regulating pRb/p130 and abrogating cell cycle checkpoints by HPV-58 E7, which also correlates with the biological risks of cervical cancer progression associated with HPV-58 infection. (C) 2009 Elsevier Inc. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-73949091825&doi=10.1016%2fj.virol.2009.10.051&partnerID=40&md5=c49f9a278d1090675f0394799e13fa50
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