标题：Differences in Sensitivity to Environment Depending on Catechol-O-Methyltransferase (COMT) Gene? A Meta-analysis of Child and Adolescent Gene-by-Environment Studies
作者：Cao, Cong; Cao, Lili; Chen, Jie
作者机构：[Cao, Cong] Shandong Univ, Sch Nursing, Jinan, Shandong, Peoples R China.; [Cao, Lili] Shandong Univ, Student Counseling Ctr, Jinan, Shandong, Peopl 更多
通讯作者：Cao, C;Chen, J
通讯作者地址：[Cao, C]Shandong Univ, Sch Nursing, Jinan, Shandong, Peoples R China;[Chen, J]Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R 更多
来源：JOURNAL OF YOUTH AND ADOLESCENCE
关键词：Meta-analysis; COMT; Gene-by-environment interaction (GxE); Child;; Adolescent
摘要：To date, several gene-by-environment (GxE) meta-analyses have been conducted to provide cumulative GxE evidence from previous inconsistent empirical studies; however, these meta-analyses have mainly focused on the serotonin transporter gene (5-HTTLPR). The present study aimed to conduct the first meta-analysis that tested whether and how an important dopaminergic genethe catechol-O-methyltransferase (COMT) gene contributed to differences in child and adolescent environmental sensitivity. A total of 22 studies with 20,528 participants involving in various developmental outcomes (e.g., externalizing problems, emotional problems, cognitive development and social behaviors) met the inclusion criteria. The pooled effect size of environment-outcome associations in the Met-allele carriers (r=0.11, 95% CI=[0.07, 0.15], p<.001) did not significantly differ from that in the Val/Val homozygotes (r=0.14, 95% CI=[0.08, 0.20], p<0.001) (Q(contrast) (1)=0.37, p=0.54). The aggregated Liptak-Stouffer Z-score that combined the p-values of the COMT-environment interaction yield a nonsignificant result (p=0.52). Moreover, outcome domain, sample age, ethnicity and assessment methods for the environment and the outcome did not moderate the effect sizes. Thus far, the COMT Val158Met polymorphism fails to explain the differences in sensitivity to environment. Future studies might incorporate more factors, such as polygenic effects of genetic pathways, epigenetics (EpiG) processing and sexual dimorphism, into the COMT-environment interaction equation.