标题:The role of antibody delivery formation in cancer therapy
作者:Qi T.; Shi Y.; Huang Y.; Fu X.; Qiu S.; Sun Q.; Lin G.
作者机构:[Qi, T] School of Pharmaceutical Science, Shandong University, Jinan, China;[ Shi, Y] School of Mechanical & Automotive Engineering, Qilu University o 更多
通讯作者:Lin, G(guimeilin@sdu.edu.cn)
通讯作者地址:[Lin, G] School of Pharmaceutical Science, Shandong UniversityChina;
来源:Journal of Drug Targeting
出版年:2020
DOI:10.1080/1061186X.2020.1728537
关键词:Antibody; antibody-drug conjugate; delivery system; liposome; nanoparticle
摘要:Cancer has become one of the major threats to human survival. Because of antibodies specificity and low toxicity, it is the primary choice to diagnose and treat cancer. It is easy to be cleared from the blood circulation or distributing throughout the body and causes unnecessary side effects. It is necessary to delivery antibodies to the tumour region in a stable, safe and effective manner. In this review, we discuss the latest studies that aimed to delivery antibodies to tumour sites via several vector forms, such as liposomes, carbon nanomaterials, and gold nanomaterials. How to deliver antibodies to the target site is a difficulty for antibody therapy. This review summarises the antibody’s therapeutic forms and carrier materials in recent years, and to explore how antibodies can be safely and stably delivered to the target site. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
收录类别:SCOPUS
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079705561&doi=10.1080%2f1061186X.2020.1728537&partnerID=40&md5=ed1b29628752aa233bc04cc1b1f3f811
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