标题：The fluoro-thiazolylhydrazone compound TSC-3C inhibits triple negative breast cancer (TNBC) cell line activity by promoting apoptosis, regulating the mapk pathway and inducing mitochondrial dysfunction
作者：Zhang J.; Dai J.; Zheng Q.; Guo S.; Yu Y.; Hu W.; Gao Y.; Shi D.
作者机构：[Zhang, J] Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China, Laboratory for 更多
通讯作者地址：[Shi, D] Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of SciencesChina;
来源：International Journal of Molecular Sciences
关键词：Apoptosis; Fluoro-thiazolylhydrazone; MAPK pathway; MDA-MB-231 cells; Phosphorylated c-Jun N-terminal kinase (p-JNK); Phosphorylated p44/42 MAPK (ERK1/2); Triple negative breast cancer
摘要：Triple negative breast cancer (TNBC) is the most aggressive cancer in women, and despite improved treatments, it remains a major cause of morbidity and mortality. We and others have demonstrated that different hybrid compounds targeting PARP/MAPK or other pathways to inhibit cancer progression may lead to promising therapeutic results. We introduced fluorine to alter the physical properties of the compounds. TSC-3C was one of the generated compounds. Upon treatment with TSC-3C, MDA-MB-231 cell proliferation, invasion, and migration were inhibited. TSC-3C induced MDA-MB-231 cell mitochondrial dysfunction and apoptosis, which may be caused by reducing the level of phosphorylated p44/42 MAPK (ERK1/2) and increasing the level of p-JNK. The present study may help to elucidate the role of the MAPK pathway in the development of breast cancer and may promote further research on halogenated heterocyclic compounds for the treatment of breast cancer. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.