标题：Ultra-sensitive film sensor based on Al2O3–Au nanoparticles supported on PDDA-functionalized graphene for the determination of acetaminophen
作者：Li, Jianbo ;Sun, Weiyan ;Wang, Xiaojiao ;Duan, Huimin ;Wang, Yanhui ;Sun, Yuanling ;Ding, Chaofan ;Luo, Chuannan
作者机构：[Li, Jianbo ;Sun, Weiyan ;Wang, Xiaojiao ;Duan, Huimin ;Wang, Yanhui ;Sun, Yuanling ;Ding, Chaofan ;Luo, Chuannan ] Key Laboratory of Chemical Sensing 更多
来源：Analytical and Bioanalytical Chemistry
摘要：An electrochemical sensor of acetaminophen based on poly(diallyldimethylammonium chloride) (PDDA)-functionalized reduced graphene-loaded Al2O3–Au nanoparticles coated onto glassy carbon electrode (Al2O3–Au/PDDA/reduced graphene oxide (rGO)/glass carbon electrode (GCE)) were prepared by layer self-assembly technique. The as-prepared electrode-modified materials were characterized by scanning electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy. The electrocatalytic performances of Al2O3–Au/PDDA/rGO-modified glassy carbon electrode toward the acetaminophen were investigated by cyclic voltammetry and differential pulse voltammetry. The modified electrodes of graphene oxide (GO)/GCE, PDDA/rGO/GCE, and Al2O3–Au/PDDA/rGO/GCE were constructed for comparison and learning the catalytic mechanism. The research showed Al2O3–Au/PDDA/rGO/GCE having good electrochemical performance, attributing to the synergetic effect that comes from the special nanocomposite structure and physicochemical properties of Al2O3–Au nanoparticles and graphene. A low detection limit of 6 nM (S/N = 3) and a wide linear detection range from 0.02 to 200 μM (R2= 0.9970) was obtained. The preparation of sensor was successfully applied for the detection of acetaminophen in commercial pharmaceutical pills. [Figure not available: see fulltext.]
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