标题：The Role of Sirt6 in Obesity and Diabetes
作者：Kuang, Jiangying; Chen, Lei; Tang, Qin; Zhang, Jinhang; Li, Yanping; He, Jinhan
作者机构：[Kuang, Jiangying; Chen, Lei; Tang, Qin; Zhang, Jinhang; Li, Yanping; He, Jinhan] Sichuan Univ, West China Hosp, Dept Pharm, State Key Lab Biotherapy, 更多
通讯作者：He, JH;He, JH
通讯作者地址：[He, JH]Sichuan Univ, West China Hosp, Dept Pharm, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China;[He, JH]Sichuan Univ, West China Hosp, 更多
来源：FRONTIERS IN PHYSIOLOGY
关键词：Sirt6; obesity; diabetes mellitus; type 2; LiPo; gluconeogenesis
摘要：Sirt6 is one of the sirtuin family members, a kind of NAD+-Hdependent histone deacetylase and ADP-ribose transferase enzyme. It has an important role in physiological and pathological processes, regulating aging, cancer, obesity, insulin resistance, inflammation, and energy metabolism. Recent studies have suggested that reduced Sirt6 action is related to obesity and diabetes. Aging and overnutrition, two major risk factors for obesity and diabetes, lead to decreased Sirt6 level and function, which results in abnormal glucose and lipid metabolism. Whole-body ablation of Sirt6 in mice results in severe hypoglycemia. Sirt6 deficiency leads to liver steatosis and promotes diet-induced obesity and insulin resistance. Sirt6 has a protective effect on obesity and diabetes. This review surveys evidence for an emerging role of Sirt6 as a regulator of metabolism in mammals and summarizes its major functions in obesity and diabetes.