标题:The genetic association between pri-miR-34b/c polymorphism (rs4938723 T > C) and susceptibility to cancers: evidence from published studies
作者:Li, Xiaowei;Wang, Liguang;Yu, Jianyu;Xu, Jun;Du, Jiajun
作者机构:[Li, X] Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan, 250021, Ch 更多
通讯作者:Du, JJ
通讯作者地址:[Du, JJ]Shandong Univ, Shandong Prov Hosp, Inst Oncol, 324 Jingwu Rd, Jinan 250021, Peoples R China.
来源:Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine
出版年:2014
卷:35
期:12
页码:12525-12534
DOI:10.1007/s13277-014-2572-y
关键词:Single nucleotide polymorphism;Pri-miR-34b/c;Cancer susceptibility;Meta-analysis
摘要:Recently, several molecular epidemiological studies have focused on the association between pri-miR-34b/c rs4938723 SNP and the susceptibility to different cancers. Due to the controversial rather than conclusive results, we performed this meta-analysis to assess more precise and comprehensive conclusion about the association. Data published until July 2014 were collected from PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure, Wanfang Data, Chinese BioMedical Literature Database, and VIP database of Chinese Journal. Ultimately, 13 articles with a total of 7,753 cases and 8,014 controls were considered eligible for inclusion. The odds ratio (OR) and its 95 % confidence interval (95%CI) were used to assess the strength of association. In the overall analysis, a significant association between pri-miR-34b/c rs4938723 polymorphism and increased cancer susceptibility was found in heterozygous model (TC vs. TT: OR=1.148, 95%CI 1.034-1.275, P=0.010) and dominant model (CC+TC vs. TT: OR=1.166, 95%CI 1.028-1.322, P=0.017). In subgroup analysis of ethnicity, pri-miR-34b/c rs4938723 polymorphism was significantly associated with an increased cancer susceptibility for Asian population in heterozygous model (TC vs. TT: OR=1.169, 95% CI 1.031-1.326, P=0.015) and dominant model (CC+TC vs. TT: OR=1.185, 95% CI 1.017-1.382, P=0.030), whereas no significant association for Caucasian population was observed in any genetic models. Intriguingly, stratified analysis revealed opposite results that pri-miR-34b/c polymorphism contributed to susceptibility to hepatocellular carcinoma while reduced susceptibility to colorectal cancer and esophageal squamous cell cancer in Asians. Considering some limitation of our meta-analysis, future well-designed case-control studies with larger sample sizes are required to confirm our findings.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:3
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925283830&doi=10.1007%2fs13277-014-2572-y&partnerID=40&md5=c2d002c80ee6e3b520b1b3b88a6695f6
TOP