标题：Chemical composition, antioxidant, antibacterial and cytotoxic activities of essential oil of Leontopodium leontopodioides (Willd.) Beauverd
作者：Gao, Yang; Rao, Huijuanzi; Mao, Ling-Jing; Ma, Qing-Lin
作者机构：[Gao, Yang; Rao, Huijuanzi; Mao, Ling-Jing; Ma, Qing-Lin] Shandong Univ, Marine Coll, Weihai, Peoples R China.
通讯作者地址：[Ma, QL]Shandong Univ, Marine Coll, Weihai, Peoples R China.
来源：NATURAL PRODUCT RESEARCH
关键词：Leontopodium leontopodioides (Willd; ) Beauverd; essential oil; GC-MS;; antibacterial activity; antioxidant activity; cytotoxic activity
摘要：The essential oil (EO) from the aerial parts of Leontopodium leontopodioides (Willd.) Beauverd was obtained by hydrodistillation and analysed by GC-FID and GC-MS. Sixty-five compounds were identified which represent 96.2% of the total composition of the EO. The major components of the EO were palmitic acid (11.6%), n-pentadecanal (5.7%), linalool (3.8%), beta-ionone (3.3%), hexahydrofarnesyl acetone (3.2%), bisabolone (3.2%) and beta-caryophyllene (3.2%). The EO exhibited an excellent antibacterial activity against Staphylococcus aureus and Bacillus subtilis according to the MIC values tested by micro-dilution method. It also exhibited a significant cytotoxicity against HepG2 and MCF-7 cell lines with the IC50 values of 67.44 and 70.49 mu g/mL according to the MTT assay. However, the antioxidant activity test revealed that the EO exhibited a weak DPPH radical-scavenging activity. In conclusion, the EO of L. leontopodioides could be regarded as a bioactive natural product and deserves further study for its potential therapeutic effects.; [GRAPHICS]; .