标题:An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene
作者:Yang Xiaomeng; Yong, Liu; Zhou Tiancheng; Zhang Haiyan; Rui, Dong; Yue, Li; Ning, Liu; Yi, Liu; Gai, Zhongtao
作者机构:[Yang Xiaomeng; Yong, Liu; Zhang Haiyan; Rui, Dong; Yue, Li; Ning, Liu; Yi, Liu; Gai, Zhongtao] Shandong Univ, Qilu Childrens Hosp, Pediat Res Inst, J 更多
通讯作者:Yi, L;Gai, ZT
通讯作者地址:[Yi, L; Gai, ZT]Shandong Univ, Qilu Childrens Hosp, Pediat Res Inst, Jinan 250022, Shandong, Peoples R China.
来源:STEM CELL RESEARCH
出版年:2019
卷:41
DOI:10.1016/j.scr.2019.101635
摘要:Autism spectrum disorder (ASD) is a childhood-onset neurodevelopmental disorder challenged in social reciprocity and restrictive repetitive behaviors. Here, we generated an induced pluripotent stem cell (iPSC) line SDQLCHi014-A from a patient with ASD and hyperactivity, carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene by reprogramming urine cells with non-integrating vectors. SDQLCHi014-A have shown full pluripotency, differentiation capacity and genetic stability. This iPSC line provides a valuable resource to study the molecular mechanisms underlying ASD.
收录类别:SCIE
资源类型:期刊论文
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