标题：Exploration of the Radiotherapeutic Clinical Target Volume Delineation for Gastric Cancer from Lymph Node Metastases
作者：Dong, Wei; Li, Baosheng; Wang, Juan; Song, Yipeng; Zhang, Zicheng; Fu, Chengrui
通讯作者：Song, YP;Li, BS
作者机构：[Dong, Wei] Shandong Univ, Sch Med, Jinan, Shandong, Peoples R China.; [Dong, Wei; Song, Yipeng] Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, R 更多
会议名称：China-United Kingdom Cancer (CUKC) Conference
会议日期：APR 22-23, 2017
关键词：Gastric cancer; radiotherapy; regional lymph nodes; delineation
摘要：Aim: To clarify the clinical target volume of regional lymph nodes (CTVn) delineation of gastric adenocarcinoma. Materials and Methods: The pattern of lymph node metastases (LNM) of a total of 1,473 patients with gastric cancer (GC) who had undergone gastrectomy and lymphadenectomy with more than 15 lymph nodes retrieved was retrospectively examined. Results: A univariate analysis showed that T stage (p<0.001), macroscopic type (p=0.001), tumor differentiation (p<0.001), maximum diameter of tumor (p<0.001) as well as cancer embolus (p<0.001) were closely associated with the rate of LNM. While by multivariate analysis, gender [odds ratio (OR=0.687, p<0.05], maximum diameter (OR=1.734, p<0.001), tumor differentiation (OR=1.584, p<0.001), T stage (OR=2.066, p<0.001) and cancer embolus (OR=4.912, p<0.001) were strongly associated with the rate of LNM. Conclusion: In conclusion, for male patients with GC with large, deeply invasive, poorly differentiated, diffusely infiltration and positive cancer embolus, the radiation fields should be enlarged appropriately.