标题：Plasma level of mitochondrial coupling factor 6 increases in patients with type 2 diabetes mellitus
作者：Li, Xiao Lu; Xing, Qi Chong; Dong, Bo; Gao, Yan Yan; Xing, Shan Shan; Pang, Yong Zheng; Jiang, Hong Feng; Tang, Chao Shu
作者机构：[Li, XL; Xing, QC; Dong, B; Gao, YY; Xing, SS; Pang, YZ; Jiang, HF; Tang, CS]Shandong Univ, Sch Med, Shandong, Peoples R China.;[Li, XL; 更多
通讯作者地址：[Xing, QC]Qianfoshan Hosp, Dept Cardiovasc Dis, 66 Jingshi Rd, Jinan 250014, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CARDIOLOGY
关键词：coupling factor 6; prostacyclin; type 2 diabetes
摘要：Coupling factor 6 (CF6) is a novel endogenous inhibitor of prostacyclin. Plasma CF6 and 6-keto-PGF(Ia) were measured by radioimmunoassay in 70 consecutively recruited patients with type 2 diabetes and in 56 healthy controls. A significantly increased plasma CF6 level was found in diabetics compared with controls. The CF6 level was inversely correlated with plasma 6-keto-PGF(Ia) level and positively correlated with blood glucose and lipids. These results suggest that CF6 might be an obvious marker of impaired endothelium and might contribute to vascular damage in diabetes. (c) 2006 Elsevier Ireland Ltd. All rights reserved.