标题：The Interplay Between Pattern Recognition Receptors and Autophagy in Inflammation
作者：Zhu, Yun; Deng, Jian; Nan, Mei-Ling; Zhang, Jing; Okekunle, Akinkunmi; Li, Jiang-Yuan; Yu, Xiao-Qiang; Wang, Pei-Hui
作者机构：[Nan, Mei-Ling; Zhang, Jing; Wang, Pei-Hui] Shandong Univ, Adv Med Res Inst, Jinan 250012, Shandong, Peoples R China.; [Zhu, Yun] Guangzhou Med Univ 更多
通讯作者地址：[Wang, PH]Shandong Univ, Adv Med Res Inst, Jinan 250012, Shandong, Peoples R China.
来源：AUTOPHAGY REGULATION OF INNATE IMMUNITY
关键词：PRRs; Autophagy; TLRs; NLRs; cGAS-STING; RLRs; RAGE; HMGB1;; Calreticulin; HSPs
摘要：Pattern recognition receptors (PRRs) are sensors of exogenous and endogenous "danger" signals from pathogen-associated molecular patterns (PAMPs), and damage associated molecular patterns (DAMPs), while autophagy can respond to these signals to control homeostasis. Almost all PRRs can induce autophagy directly or indirectly. Toll-like receptors (TLRs), Nod-like receptors (NLRs), retinoic acid-inducible gene-I-like receptors (RLRs), and cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway can induce autophagy directly through Beclin-1 or LC3-dependent pathway, while the interactions with the receptor for advanced glycation end products (RAGE)/high mobility group box 1 (HMGB1), CD91/Calreticulin, and TLRs/HSPs are achieved by protein, Ca2+, and mitochondrial homeostasis. Autophagy presents antigens to PRRs and helps to clean the pathogens. In addition, the induced autophagy can form a negative feedback regulation of PRRs-mediated inflammation in cell/disease-specific manner to maintain homeostasis and prevent excessive inflammation. Understanding the interaction between PRRs and autophagy in a specific disease will promote drug development for immunotherapy. Here, we focus on the interactions between PRRs and autophagy and how they affect the inflammatory response.