标题:Recent Advances in the DABOs Family as Potent HIV-1 non-Nucleoside Reverse Transcriptase Inhibitors
作者:Yu, Mingyan; Fan, Erkang; Wu, Jingde; Liu, Xinyong
作者机构:[Yu, Mingyan; Wu, Jingde; Liu, Xinyong] Shandong Univ, Sch Pharm, Inst Med Chem, Jinan 250012, Peoples R China.; [Fan, Erkang] Univ Washington, Dept 更多
通讯作者:Liu, XY
通讯作者地址:[Liu, XY]Shandong Univ, Sch Pharm, Inst Med Chem, Jinan 250012, Peoples R China.
来源:CURRENT MEDICINAL CHEMISTRY
出版年:2011
卷:18
期:16
页码:2376-2385
DOI:10.2174/092986711795843209
关键词:AIDS; DABOs; HAART; HIV; NNRTIs; RT; SAR
摘要:HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to an allosteric site on reverse transcriptase (RT) and are a key component of highly active anti-retroviral therapy (HAART) combination regimen for clinical treatment of HIV/AIDS. However, the rapid emergence of drug resistance has limited NNRTIs' clinical option. Therefore, there is an urgent need for the design and development of new and safe NNRTIs that are specifically active against drug-resistant viral strains. DABOs family is one representative of the reported potent HIV-1 NNRTIs, with robust anti-HIV-1 activity against both the wild-type (wt) and drug-resistant isolates carrying multiple RT gene mutations. Three generations of DABO analogues have been studied up to now, i.e.: dihydroalkyloxybenzyloxopyrimidines (O-DABOs), dihydroalkylthiobenzyloxopyrimidines (S-DABOs) and dihydroalkylaminodifluorobenzyloxopyrimidines (N-DABOs), from which many promising DABOs are under developed. The recent research of the DABOs family in antiviral activity, structure activity relationships (SAR), and interaction model with the HIV-1 RT are reviewed in this paper.
收录类别:SCOPUS;SCIE
WOS核心被引频次:11
Scopus被引频次:12
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-79957943089&doi=10.2174%2f092986711795843209&partnerID=40&md5=8450d01db0aefcda96d20ff007f806c1
TOP