标题:FGF2 regulates melanocytes viability through the STAT3-transactivated PAX3 transcription
作者:Dong, L.; Li, Y.; Cao, J.; Liu, F.; Pier, E.; Chen, J.; Xu, Z.; Chen, C.; Wang, R-A; Cui, R.
作者机构:[Dong, L.; Li, Y.; Cao, J.; Liu, F.; Pier, E.; Chen, J.; Cui, R.] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA.; [Dong, L.] Shandong Un 更多
通讯作者:Cui, R
通讯作者地址:[Cui, R]Boston Univ, Sch Med, Dept Dermatol, 609 Albany Sreet, Boston, MA 02118 USA.
来源:CELL DEATH AND DIFFERENTIATION
出版年:2012
卷:19
期:4
页码:616-622
DOI:10.1038/cdd.2011.132
关键词:UV; melanocyte; pigment; PAX3
摘要:PAX3 (paired box 3) is known to have an important role in melanocyte development through modulation of microphthalmia-associated transcription factor transcription. Here we found that PAX3 transcriptional activity could be regulated through FGF2 (basic fibroblast growth factor)-STAT3 (signal transducer and activator of transcription 3) signaling in the pigment cells. To study its function in vivo, we have generated a transgenic mouse model expressing PAX3 driven by tyrosinase promoter in a tissue-specific fashion. These animals exhibit hyperpigmentation in the epidermis, evident in the skin color of their ears and tails. We showed that the darker skin color results from both increased melanocyte numbers and melanin synthesis. Together, our study delineated a novel pathway in the melanocyte lineage, linking FGF2-STAT3 signaling to increased PAX3 transcription. Moreover, our results suggest that this pathway might contribute to the regulation of melanocyte numbers and melanin levels, and thereby provide an alternative strategy to induce pigmentation. Cell Death and Differentiation (2012) 19, 616-622; doi:10.1038/cdd.2011.132; published online 14 October 2011
收录类别:SCOPUS;SCIE
WOS核心被引频次:16
Scopus被引频次:15
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84858155299&doi=10.1038%2fcdd.2011.132&partnerID=40&md5=c3b378831ac4bf926c3116de44749dca
TOP