标题：Advancement of multifunctional hybrid nanogel systems: Construction and application in drug co-delivery and imaging technique
作者：Ma, Yakun; Ge, Yanxiu; Li, Lingbing
作者机构：[Ma, Yakun; Ge, Yanxiu; Li, Lingbing] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China.
通讯作者地址：[Li, LB]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Jinan 250012, Shandong, Peoples R China.
来源：MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
关键词：Multifunctional hybrid nanogel; Drug delivery system; Multicompartment; nanogel; Stimuli-responsive; Multiple agents co-delivery; Imaging; contrast
摘要：Nanogel-based multifunctional drug delivery systems, especially hybrid nanogels and multicompartment nanogels have drawn more and more extensive attention from the researchers in pharmacy because it can result in achieving a superior functionality through the synergistic property enhancement of each component The unique hybrid and compartmentalized structures provide the great potential for co-delivery of multiple agents even the multiple agents with different physicochemical properties. Otherwise the hybrid nanogel encapsulating optical and magnetic resonance imaging contrast can be utilized in imaging technique for disease diagnosis. More importantly through nanogel-based multifunctional drug delivery systems the stimuli-responsive features might be easily employed for the design of targeted release of drug. This review summarizes the construction of diverse hybrid nanogels and multicompartment nanogels. The application in co-delivery of multiple agents and imaging agents for diagnosis as well as the application in the design of stimuli-responsive multifunctional nanogels as drug delivery are also reviewed and discussed. The future prospects in application of multifunctional nanogels will be also discussed in this review. (C) 2016 Elsevier B.V. All rights reserved.