标题:Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos
作者:Ning, Nannan; Zhu, Jianchun; Du, Yahui; Gao, Xiaolin; Liu, Chuanyong; Li, Jingxin
作者机构:[Ning, Nannan; Zhu, Jianchun; Du, Yahui; Liu, Chuanyong; Li, Jingxin] Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Peoples R China.; [Gao, Xi 更多
通讯作者:Li, JX
通讯作者地址:[Li, JX]Shandong Univ, Sch Med, Dept Physiol, Jinan 250012, Peoples R China.
来源:NATURE COMMUNICATIONS
出版年:2014
卷:5
DOI:10.1038/ncomms5107
摘要:Embryo retention in the fallopian tube is thought to lead to ectopic pregnancy, which is a significant cause of morbidity. Hydrogen sulphide (H2S) is a gaseotransmitter produced mainly by cystathionine-gamma-lyase and cystathionine-beta-synthase. Here we show that cystathionine-gamma-lyase and cystathionine -beta-synthase are ubiquitously distributed in human fallopian tube epithelium and that H2S signalling relaxes the spontaneous contraction of the human oviduct. Furthermore, an aberration in H2S signalling, either silenced or enhanced activity induced by pharmacologic or genetic methods, causes embryo retention and developmental delay in the mouse oviduct, which is partly reversed by administration of either GYY4137, a slow-releasing H2S donor, or NaHS. Our findings reveal a new regulatory mechanism for oviductal embryo transport.
收录类别:SCOPUS;SCIE
WOS核心被引频次:13
Scopus被引频次:14
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84902321996&doi=10.1038%2fncomms5107&partnerID=40&md5=fda5de4ecfb0d1691156ae22dc652ec3
TOP