标题:A review of the ligands and related targeting strategies for active targeting of paclitaxel to tumours
作者:Li, Juan; Wang, Fengshan; Sun, Deqing; Wang, Rongmei
作者机构:[Li, Juan; Sun, Deqing; Wang, Rongmei] Shandong Univ, Dept Pharm, Hosp 2, Jinan 250033, Shandong, Peoples R China.; [Wang, Fengshan] Shandong Univ, 更多
通讯作者:Wang, RM
通讯作者地址:[Wang, RM]Shandong Univ, Dept Pharm, Hosp 2, Jinan 250033, Shandong, Peoples R China.
来源:JOURNAL OF DRUG TARGETING
出版年:2016
卷:24
期:7
页码:590-602
DOI:10.3109/1061186X.2016.1154561
关键词:Active tumour targeting; ligands; monoclonal antibodies; protein and; oligopeptides; paclitaxel; polysaccharide; small targeting molecules
摘要:It has been 30 years since the discovery of the anti-tumour property of paclitaxel (PTX), which has been successfully applied in clinic for the treatment of carcinomas of the lungs, breast and ovarian. However, PTX is poorly soluble in water and has no targeting and selectivity to tumour tissue. Recent advances in active tumour targeting of PTX delivery vehicles have addressed some of the issues related to lack of solubility in water and non-specific toxicities associated with PTX. These PTX delivery vehicles are designed for active targeting to specific cancer cells by the addition of ligands for recognition by specific receptors/antigens on cancer cells. This article will focus on various ligands and related targeting strategies serving as potential tools for active targeting of PTX to tumour tissues, illustrating their use in different tumour models. This review also highlights the need of further studies on the discovery of receptors in different cells of specific organ and ligands with binding efficiency to these specific receptors.
收录类别:SCOPUS;SCIE
WOS核心被引频次:9
Scopus被引频次:10
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961215737&doi=10.3109%2f1061186X.2016.1154561&partnerID=40&md5=537e0851471978488f3857570dbdd727
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