标题：Lipoprotein lipase gene Hind III polymorphism was associated with hemorrhagic stroke
作者：Zhang, Wen-Sheng; Zhang, Wen-Hua; Liu, Qi-Ji
作者机构：[Zhang, Wen-Sheng; Zhang, Wen-Hua] Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan 250012, Peoples R China.; [Liu, Qi-Ji] Shandong Univ, Sch Med, De 更多
通讯作者地址：[Zhang, WH]Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan 250012, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
关键词：Cerebral hemorrhage; lipoprotein lipase; polymerase chain reaction; gene; frequencies; genotype; risk factors
摘要：Objective: To investigate the relevance between lipoprotein lipase (LPL) Hind III gene polymorphism and cerebral hemorrhage. Methods: A case-control study was performed utilizing PCR-RFLP method and sequencing of amplified products to detect LPL Hind III gene polymorphism in 350 cases of hemorrhagic stroke (HS group) and 350 healthy subjects (control group). Blood lipids and glucose levels were also recorded for each attendant. Results: In HS group, T and G allele frequencies were 90.8% and 9.2%, respectively; while those in the control group were 82.3% and 17.7%. In HS group, detection rate of the G allele frequency and GG genotype were significantly lower than those in the control group. In addition, TG, LDL-C, fasting blood glucose, systolic blood pressure, diastolic blood pressure were significantly higher in HS group (P<0.05, P<0.01). Compared with TG+GG genotype, TT genotype population show significantly higher triglycerides concentration (P<0.05). With adjustment for hypertension, high blood sugar, and age -related factors, multivariate logistic regression analysis showed that LPL Hind III G allele could be a protective factor (OR = 0.392, 95% CI: 0.191 similar to 0.805, P = 0.011). Conclusion: LPL Hind III gene polymorphism was relevant to hemorrhagic stroke. LPL Hind III G mutant allele could be a protective factor in the pathogenesis of cerebral hemorrhage.