标题:1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents
作者:Z. Li;P. Zhan;X. Liu
作者机构:[Li, Z] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, 250012, Jinan, Shandong, Chi 更多
通讯作者:Liu, X
通讯作者地址:[Liu, X]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, 44 W Culture Rd, Jinan 250012, Shandong, Peoples R China.
来源:Mini reviews in medicinal chemistry
出版年:2011
卷:11
期:13
页码:1130-1142
DOI:10.2174/138955711797655407
关键词:1;3;4-Oxadiazole;privileged structure;solid-phase synthesis;antiviral activity;structural modification;molecule modeling.
摘要:1,3,4-oxadiazole, a privileged structure, endows its derivatives with broad and potent biological functions, especially in antiviral activities, including anti-HIV, anti-HCV, anti-HBV, anti-HSV activities, etc. Molecular modeling and pharmacokinetic studies have demonstrated that the introduction of 1,3,4-oxadiazole ring to the inhibitors can change their polarity, flexibility as well as metabolic stability, and 1,3,4-oxadiazole scaffold can also act as acceptors of hydrogen bonds formation, which make it possible to be used as a isosteric substituent for amide or ester groups. This review focuses on the recent advances in the synthesis of 1,3,4-oxadiazole ring and mainly the discovery, biological activities investigations and structural modifications of several distinct classes of 1,3,4-oxadiazoles as potent antiviral agents. In addition, the binding models of some representative 1,3,4-oxadiazoles were also discussed, which provide rational explanation for their interesting antiviral activities, and also pave the way for further optimization of 1,3,4-oxadiazole based antiviral agents.
收录类别:SCOPUS;SCIE
WOS核心被引频次:41
Scopus被引频次:45
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054055210&doi=10.2174%2f138955711797655407&partnerID=40&md5=6abad6fdf46586f2df8a11ea52a16058
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