标题:Synthesis and antibacterial activity of novel 4\'\'-O-arylalkylcarbamoyl and 4\'\'-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives.
作者:Ju Y;Xian R;Zhang L;Ma R;Cao J;Ma S
作者机构:[Ju, Y] Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, 44, West Culture Road, Jinan, 250012, China;[ Xian, 更多
通讯作者:Ma, ST
通讯作者地址:[Ma, ST]Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, 44 W Culture Rd, Jinan 250012, Peoples R China.
来源:Bioorganic and Medicinal Chemistry Letters
出版年:2010
卷:20
期:11
页码:3272-3274
DOI:10.1016/j.bmcl.2010.04.051
关键词:Clarithromycin derivatives; Synthesis; Antibacterial activity; Bacterial; resistance
摘要:Novel series of novel 4\'\'-O-arylalkylcarbamoyl and 4\'\'-O-((arylalkylamino)-4-oxo-butyl)carbamoyl clarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. These derivatives retained excellent activity against the erythromycin-susceptible strains and showed significantly improved activity against all of the tested erythromycin-resistant strains. Among them, compound 4c was the most effective (0.06 microg/mL) against Streptococcus pneumonia encoded by the erm gene and compound 4a was had the most potent activity (0.25 microg/mL) against S. pneumonia encoded by the erm and mef genes.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953285616&doi=10.1016%2fj.bmcl.2010.04.051&partnerID=40&md5=7d179c47f6dce6a72ba014b9f8228760
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