标题:Update of research on the role of EZH2 in cancer progression
作者:Shen, Liang; Cui, Jing; Liang, Shumei; Pang, Yingxin; Liu, Peishu
作者机构:[Shen, Liang; Pang, Yingxin; Liu, Peishu] Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Jinan 250012, Shandong, Peoples R China.; [Cui, Jing] Jin 更多
通讯作者:Liu, PS
通讯作者地址:[Liu, PS]Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Wen Hua Xi Lu 107, Jinan 250012, Shandong, Peoples R China.
来源:ONCOTARGETS AND THERAPY
出版年:2013
卷:6
页码:321-324
DOI:10.2147/OTT.S42453
关键词:EZH2; PRC2; cancer
摘要:Accumulating evidence shows that enhancer of zeste homolog 2 (E2H2) is upregulated in a broad range of cancer types, such as breast cancer, prostate cancer, ovarian cancer, and colon cancer. Therefore, inhibiting EZH2 expression may be a promising strategy for anticancer therapy. This review focuses on the current understanding of the mechanisms underlying EZH2 regulation that are involved in cancer progression. Also, it introduces two EZH2 inhibitors that target EZH2 and could be potentially applied in the treatment of cancer in the future.
收录类别:SCOPUS;SCIE
WOS核心被引频次:19
Scopus被引频次:21
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875993688&doi=10.2147%2fOTT.S42453&partnerID=40&md5=2cf0f35673c8a2ccd0d52755162b3119
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