标题：Insulin-like growth factor binding protein-related protein 1 and cancer
作者：Zhu, Shuzhen; Xu, Fangying; Zhang, Jing; Ruan, Wenjing; Lai, Maode
作者机构：[Zhu, Shuzhen; Xu, Fangying; Zhang, Jing; Lai, Maode] Zhejiang Univ, Sch Med, Dept Pathol, Hangzhou 310058, Zhejiang, Peoples R China.; [Zhu, Shuzhe 更多
通讯作者地址：[Lai, MD]Zhejiang Univ, Sch Med, Dept Pathol, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
来源：CLINICA CHIMICA ACTA
关键词：IGF; IGFBP-rP1; Cancer
摘要：Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) belongs to the IGFBP family whose members have a conserved structural homology. It has a low affinity for IGFs and a high affinity for insulin, suggesting that IGFBP-rP1 may have a biological function distinct from other members of the family. IGFBP-rP1 is ubiquitously expressed in normal human tissues and has diverse biological functions, regulating cell proliferation, apoptosis and senescence; it may also have a key role in vascular biology. Increasing evidence suggests that IGFBP-rP1 acts as a tumor suppressor. It elicits its biological effects by both insulin/IGF-dependent and -independent mechanisms. This paper provides a brief overview of the structure and regulation of IGFBP-rP1 and its various biological functions in cancer, as well as the underlying molecular mechanisms. (C) 2014 Elsevier B.V. All rights reserved.