标题:Insulin-like growth factor binding protein-related protein 1 and cancer
作者:Zhu, Shuzhen; Xu, Fangying; Zhang, Jing; Ruan, Wenjing; Lai, Maode
作者机构:[Zhu, Shuzhen; Xu, Fangying; Zhang, Jing; Lai, Maode] Zhejiang Univ, Sch Med, Dept Pathol, Hangzhou 310058, Zhejiang, Peoples R China.; [Zhu, Shuzhe 更多
通讯作者:Lai, MD
通讯作者地址:[Lai, MD]Zhejiang Univ, Sch Med, Dept Pathol, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
来源:CLINICA CHIMICA ACTA
出版年:2014
卷:431
页码:23-32
DOI:10.1016/j.cca.2014.01.037
关键词:IGF; IGFBP-rP1; Cancer
摘要:Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) belongs to the IGFBP family whose members have a conserved structural homology. It has a low affinity for IGFs and a high affinity for insulin, suggesting that IGFBP-rP1 may have a biological function distinct from other members of the family. IGFBP-rP1 is ubiquitously expressed in normal human tissues and has diverse biological functions, regulating cell proliferation, apoptosis and senescence; it may also have a key role in vascular biology. Increasing evidence suggests that IGFBP-rP1 acts as a tumor suppressor. It elicits its biological effects by both insulin/IGF-dependent and -independent mechanisms. This paper provides a brief overview of the structure and regulation of IGFBP-rP1 and its various biological functions in cancer, as well as the underlying molecular mechanisms. (C) 2014 Elsevier B.V. All rights reserved.
收录类别:SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:12
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893922224&doi=10.1016%2fj.cca.2014.01.037&partnerID=40&md5=3e478b468b652aba2ac6edcbb8f35a00
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