标题：Anticancer polysaccharides from natural resources: A review of recent research
作者：Zong, Aizhen; Cao, Hongzhi; Wang, Fengshan
作者机构：[Cao, Hongzhi; Wang, Fengshan] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250012, Shandong, Peoples R China.; [Zong, Aizhen; Wang, Fengshan] Shand 更多
通讯作者地址：[Wang, FS]Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250012, Shandong, Peoples R China.
关键词：Polysaccharides; Polysaccharide-protein complexes; Anticancer
摘要：Taking into account the rising trend of the incidence of cancers of various organs, effective therapies are urgently needed to control human malignancies. However, almost all of the chemotherapy drugs currently on the market cause serious side effects. Fortunately, several previous studies have shown that some non-toxic biological macromolecules, including polysaccharides and polysaccharide-protein complexes, possess anti-cancer activities or can increase the efficacy of conventional chemotherapy drugs. Based on these encouraging observations, a great deal of effort has been focused on discovering anticancer polysaccharides and complexes for the development of effective therapeutics for various human cancers. This review focuses on the advancements in the anti-cancer efficacy of various natural polysaccharides and polysaccharide complexes in the past 5 years. Most polysaccharides were tested using model systems, while several involved clinical trials. (c) 2012 Elsevier Ltd. All rights reserved.