标题:Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp.
作者:Juanli Zhang;Zhengyi Qian;Xingkang Wu;Yanjiao Ding;Jianfang Li;Chunhua Lu;Yuemao Shen
作者机构:[Zhang, J] Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road 更多
通讯作者:Shen, YM
通讯作者地址:[Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
来源:Organic letters
出版年:2014
卷:16
期:10
页码:2752-2755
DOI:10.1021/ol501072t
关键词:Juanlimycins A and B;Ansamycin;Macrodilactams
摘要:Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. This family has shown a high degree of druggability exemplified by rifamycins, maytansinoids, and geldanamycins. In this study, the isolation of two novel ansamycin macrodilactams with unprecedented features, juanlimycins A (1) and B (2), from Streptomyces sp. LC6 were reported. The structures of 1 and 2 were assigned on the basis of analysis of NMR spectroscopic data and X-ray single crystal diffraction.
收录类别:SCOPUS;SCIE
WOS核心被引频次:12
Scopus被引频次:16
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84900872952&doi=10.1021%2fol501072t&partnerID=40&md5=0d9e8ec6afd971e0c26a5b470a2f2caf
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