标题：Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp.
作者：Juanli Zhang;Zhengyi Qian;Xingkang Wu;Yanjiao Ding;Jianfang Li;Chunhua Lu;Yuemao Shen
作者机构：[Zhang, J] Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road 更多
通讯作者地址：[Shen, YM]Shandong Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Chem Biol, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
关键词：Juanlimycins A and B;Ansamycin;Macrodilactams
摘要：Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. This family has shown a high degree of druggability exemplified by rifamycins, maytansinoids, and geldanamycins. In this study, the isolation of two novel ansamycin macrodilactams with unprecedented features, juanlimycins A (1) and B (2), from Streptomyces sp. LC6 were reported. The structures of 1 and 2 were assigned on the basis of analysis of NMR spectroscopic data and X-ray single crystal diffraction.