标题：IL-17A G197A gene polymorphism contributes to susceptibility for liver cirrhosis development from patients with chronic hepatitis B infection in Chinese population
作者：Ge, Jian; Yu, Yuan-Zi; Li, Tao; Guo, Zhao-Yang; Wu, Hao; Tang, Shao-Can; Liu, Xin-Guang; Zhu, Qiang
作者机构：[Ge, Jian; Yu, Yuan-Zi; Li, Tao; Zhu, Qiang] Shandong Univ, Shandong Prov Hosp, Dept Gastroenterol, Jinan 250021, Shandong, Peoples R China.; [Guo, 更多
通讯作者地址：[Zhu, Q]Shandong Univ, Shandong Prov Hosp, Dept Gastroenterol, 324,Jing 5 Rd, Jinan 250021, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
关键词：IL-17; liver cirrhosis; gene polymorphisms
摘要：Background: IL-17A G197A and IL-17F A7488G gene polymorphisms are found to be associated with the risk of several diseases, however few studies have focused on their correlation with risk of liver cirrhosis (LC). Aims: The aim of this study was to assess the impact of IL-17A G197A and IL-17F A7488G gene polymorphisms on development of LC from chronic hepatitis B (CHB) in Chinese patients. Methods: A total of 163 HBV-related LC patients and 168 CHB patients were enrolled in the present study. IL-17A and IL-17F gene polymorphisms were analyzed using a polymerase chain reaction (PCR) restriction fragment length polymorphism assay (PCR-RFLP). Results: Frequencies of IL-17A G197A genotype AA and allele A were significantly higher in LC patients compared with that in CHB patients (AA 42.33% vs 27.98%, P = 0.032; A 56.34% vs 46.15%, P=0.011, respectively); While no significant difference in frequencies of genotypes and alleles of IL-17F A7488G was found between the two groups. The AA genotype of IL-17A G197A significantly increased LC risk (OR 4.186, 95% CI: 1.479-11.844), while A allele carriers were also associated with an increased LC risk (OR 1.856, 95% CI: 1.161-2.967). Conclusion: IL-17A G197A is a candidate gene that confers the genetic susceptibility for LC development from CHB in Chinese population.