标题：Prognostic value of HE4 in patients with ovarian cancer
作者：Yuan, Cunzhong; Li, Rongrong; Yan, Shi; Kong, Beihua
作者机构：[Yuan, Cunzhong; Li, Rongrong; Yan, Shi; Kong, Beihua] Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Jinan, Shandong, Peoples R China.; [Yuan, Cu 更多
通讯作者：Yan, S;Kong, BH;Yan, S;Kong, BH
通讯作者地址：[Yan, S; Kong, BH]Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Jinan, Shandong, Peoples R China;[Yan, S; Kong, BH]Shandong Univ, Qilu Hosp, Gyneco 更多
来源：CLINICAL CHEMISTRY AND LABORATORY MEDICINE
关键词：HE4; meta-analysis; ovarian cancer; prognosis
摘要：Background: There is no consensus in the medical community about the prognostic role of preoperative serum levels of human epididymis protein 4 (HE4) in ovarian cancer (OC). The purpose of this meta-analysis was to establish whether preoperative serum levels of HE4 are associated with OC prognosis.; Content: Eligible studies were searched for in PubMed, ClinicalTrials. gov, CNKI and Wanfang Med Online. We performed a meta-analysis of 1315 OC cases from 14 published articles.; Summary: Our meta-analysis demonstrated that high HE4 was associated with poor overall survival (OS) (random effects model, hazard ratio [HR] = 1.91, 95% confidence interval [CI] = 1.40-2.614, p < 0.0001; I-2 = 52%, p = 0.04) and; progression-free survival (PFS) (random effects model, HR = 1.38, 95% CI = 1.13-1.69, p = 0.002; I-2 = 85%, p < 0.00001). However, subgroup analysis showed that high HE4 was not associated with poor OS (fixed effects model, HR = 1.86, 95% CI = 0.89-3.89, p = 0.1; I-2 = 34%, p = 0.22) or PFS (random effects model, HR = 1.34, 95% CI = 0.95-1.88, p = 0.1; I-2 = 69%, p = 0.007) for studies including only Asian populations.; Outlook: In conclusion, this meta-analysis shows that high HE4 was associated with poor OC OS and PFS overall. However, the association of high HE4 with poor OS and PFS was not observed for Asians. Large-scale, multicenter investigations should be performed.