标题:Comparison of gross tumor volume of primary oesophageal cancer based on contrast-enhanced three-dimensional, four-dimensional, and cone beam computed tomography
作者:Hu, Chao-Yue; Li, Jian-Bin; Wang, Jin-Zhi; Wang, Wei; Li, Feng-Xiang; Guo, Yan-Luan
作者机构:[Hu, Chao-Yue] Univ Jinan Shandong Acad Med Sci, Sch Med & Life Sci, Jinan, Shandong, Peoples R China.; [Hu, Chao-Yue; Li, Jian-Bin; Wang, Jin-Zhi; 更多
通讯作者:Li, JB
通讯作者地址:[Li, JB]Shandong Acad Med Sci, Shandong Univ, Shandong Canc Hosp, Dept Radiat Oncol, Jinan, Shandong, Peoples R China.
来源:ONCOTARGET
出版年:2017
卷:8
期:56
页码:95577-95585
DOI:10.18632/oncotarget.21520
关键词:oesophageal cancer; three-dimensional computed tomography;; four-dimensional computed tomography; cone beam computed tomography;; gross tumor volume
摘要:Background: To explore motion information included in 3DCT, 4DCT and CBCT by comparing volumetric and positional differences of GTV.; Results: Independent of tumor location, significant differences were observed among volumes [IGTV(10) > (IGTV(CBCT) or IGTV(MIP)) > (GTV(3D) or GTV(4D50))]. The underestimations or overestimations between IGTV(10) and IGTV(CBCT) were larger than those between IGTV(10) and IGTV(MIP) (p < 0.001-0.011; p < 0.001-0.023). For upper oesophageal tumors, GTV(4D50)/IGTV(CBCT) negatively correlated with motion vector (r = -0.756, p = 0.011). In AP direction, the centroid coordinates of IGTV(CBCT) differed from GTV(3D), GTV(4D50), IGTV(MIP) and IGTV(10) (p = 0.006, 0.013, 0.038, and 0.010). For middle oesophageal tumors, IGTV(10)/IGTV(CBCT) positively correlated with motion vector (r = 0.695, p = 0.006). The centroid coordinates of IGTV(CBCT) differed from those of IGTV(10) (p = 0.046) in AP direction. For distal oesophageal tumors, the centroid coordinates of IGTV(CBCT) showed significant differences to those of IGTV(MIP) (p = 0.042) in LR direction. For both middle and distal tumors, the degrees of associations of IGTV(10) outside IGTV(CBCT) significantly correlated with the motion vector (r = 0.540, p = 0.046; r = 0.678, p = 0.031).; Materials and Methods: Thirty-four oesophageal cancer patients underwent 3DCT, 4DCT and CBCT. GTV(3D), GTV(4D50), internal GTV(MIP) (IGTV(MIP)) and IGTV(CBCT) were delineated on 3DCT, 4DCT(50), 4DCT(MIP) and CBCT. GTVs from 10 respiratory phases were combined to produce GTV(10). Differences in volume, position for different targets, correlation between volume ratio and motion vector were evaluated. The motion vector was the spatial moving of the target centroid position.; Conclusions: IGTV(CBCT) encompasses more motion information than GTV(3D) and GTV(4D50) for upper oesophageal tumors, but slightly less than IGTV(10) for middle and distal oesophageal tumors. IGTV(CBCT) incorporated similar motion information to IGTV(MIP). However, motion information encompassed in CBCT and MIP cannot replace each other.
收录类别:SCOPUS;SCIE
WOS核心被引频次:1
Scopus被引频次:1
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033406408&doi=10.18632%2foncotarget.21520&partnerID=40&md5=1715f3d3c3cb19ea7b34799559ac172d
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