标题：Yanghe Huayan decoction inhibits the capability of trans-endothelium and angiogenesis of HER2+breast cancer via pAkt signaling
作者：Liu, Xiao-Fei; Li, Jing-Wei; Chen, Hong-Zhi; Sun, Zi-Yuan; Shi, Guang-Xi; Zhu, Jian-Min; Song, Ai-Li; Wang, Ying; Li, Xiang-Qi
作者机构：[Liu, Xiao-Fei] Shandong Univ Tradit Chinese Med, Clin Coll 1, Jinan, Shandong, Peoples R China.; [Li, Jing-Wei; Sun, Zi-Yuan; Shi, Guang-Xi; Zhu, J 更多
通讯作者：Li, JW;Li, XQ;Wang, Y
通讯作者地址：[Li, JW]Shandong Univ Tradit Chinese Med, Dept Breast Surg, Affiliated Hosp, Jinan, Shandong, Peoples R China;[Li, XQ]Taishan Med Univ, Dept Breast Su 更多
摘要：Background: Yanghe Huayan Decoction (YHD), a traditional Chinese medicine, is one of the most common complementary medicine currently used in the treatment of breast cancer (BC). It has been recently linked to suppress precancerous lesion and tumor development. The current study sought to explore the role of YHD on trans-endothelium and angiogenesis of BC. Methods: HER2+ BC cells were treated with YHD, Trastuzumab, or the combination in vitro and in vivo to compare the effects of them on trans-endothelium and angiogenesis features. The present study also investigated the potential molecular mechanism of YHD in inhibiting angiogenesis of BC. Results: YHD significantly suppressed the invasion and angiogenesis of BC cells via elevated pAkt signaling. Administration of YHD in vivo also strikingly repressed angiogenesis in tumor grafts. Conclusion: YHD could partially inhibit and reverse tumorigenesis of BC. It also could inhibit Akt activation and angiogenesis in vitro and in vivo. Its effect was superior to trastuzumab. Thus it was suitable for prevention and treatment of BC.