标题： [Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation].
作者： Su, Yunxiang; Xue, Ling
作者机构：[ Su, Yunxiang; Su Y] Laboratory of Traditional Chinese Medicine Classical Theory, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, 更多
来源： Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
摘要： OBJECTIVE: To research the effect of the Jingqianshu granule (JQS) on the expression of serotonin receptor-1A (5-HT(1A)R) in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression. METHOD: The PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT(1A)R in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot. RESULT: After the JQS were administered, the open field scores, the expression of 5-HT(1A)R mRNA and protein in hippocampus and hypothalamus of rats increased significantly. CONCLUSION: The JQS granule can up-regulate the expression of 5-HT(1A)R in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression.