标题: [Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation].
作者: Su, Yunxiang; Xue, Ling
作者机构:[ Su, Yunxiang; Su Y] Laboratory of Traditional Chinese Medicine Classical Theory, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, 更多
来源: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
出版年:2011
卷: 36
期: 24
摘要: OBJECTIVE: To research the effect of the Jingqianshu granule (JQS) on the expression of serotonin receptor-1A (5-HT(1A)R) in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression. METHOD: The PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT(1A)R in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot. RESULT: After the JQS were administered, the open field scores, the expression of 5-HT(1A)R mRNA and protein in hippocampus and hypothalamus of rats increased significantly. CONCLUSION: The JQS granule can up-regulate the expression of 5-HT(1A)R in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression.
收录类别:
资源类型:期刊论文
TOP