标题：Acid-sensing ion channels under hypoxia
作者：Guo Yingjun; Qu Xun
作者机构：[Guo Yingjun; Qu Xun] Shandong Univ, Dept Basic Med, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
通讯作者地址：[Qu, X]Shandong Univ, Dept Basic Med, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
关键词：acid-sensing ion channel; calcium ion; cell injury; hypoxia; pain;; proinflammatory factor; tumor
摘要：Hypoxia represents the lack of oxygen below the basic level, and the range of known channels related to hypoxia is continually increasing. Since abnormal hypoxia initiates pathological processes in numerous diseases via, to a great degree, producing acidic microenvironment, the significance of these channels in this environment has, until now, remained completely unknown. However, recent discovery of acid-sensing ion channels (ASICs) have enhanced our understanding of the hypoxic channelome. They belong to the degenerin/epithelial Na+ channel family and function once extracellular pH decreases to a certain level. So does the ratiocination emerge that ASICs participate in many hypoxia-induced pathological processes, including pain, apoptosis, malignancy, which all appear to involve them. Since evidence suggests that activity of ASICs is altered under pathological hypoxia, future studies are needed to deeply explore the relationship between ASICs and hypoxia, which may provide a progressive understanding of hypoxic effects in cancer, arthritis, intervertebral disc degeneration, ischemic brain injury and so on.