标题：Etanercept Attenuates Myocardial Ischemia/Reperfusion Injury by Decreasing Inflammation and Oxidative Stress
作者：Yang, Mei; Chen, Jianchang; Zhao, Jing; Meng, Mei
作者机构：[Yang, Mei] Third Hosp Jinan, Dept Crit Care Med, Jinan, Peoples R China.; [Chen, Jianchang] Shandong Prov Hosp, Dept Emergency, Jinan, Peoples R Ch 更多
通讯作者地址：[Yang, M]Third Hosp Jinan, Dept Crit Care Med, Jinan, Peoples R China.
摘要：The protective role of etanercept in myocardial ischemia/reperfusion is not well understood. The aim of this study was to investigate whether etanercept modulates neutrophil accumulation, TNF-alpha induction and oxidative stress in an ischemia/reperfusion injured rat heart model. Rats were randomly exposed to sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+ etanercept. The results demonstrated that compared to MI/R, etanercept reduced myocardial infarction area, myocardial myeloperoxidase (MPO) levels, serum creatinine kinase (CK) and lactate dehydrogenase (LDH) levels, and both serum and myocardial TNF-alpha production. Etanercept also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in MI/R rats. In summary, our data suggested that etanercept has protective effects against MI/R injury in rats, which may be attributed to attenuating inflammation and oxidative stress.