标题:The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy
作者:Zhou, Lichun; Ma, Baohua; Han, Xiuzhen
作者机构:[Zhou, Lichun; Han, Xiuzhen] Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan, Shandong, Peoples R China.; [Ma, Baohua] Cent Hosp Qingdao, P 更多
通讯作者:Han, XZ
通讯作者地址:[Han, XZ]Shandong Univ, Sch Pharmaceut Sci, Dept Pharmacol, Jinan, Shandong, Peoples R China.
来源:JOURNAL OF MOLECULAR ENDOCRINOLOGY
出版年:2016
卷:57
期:4
页码:R143-R152
DOI:10.1530/JME-16-0086
关键词:angiotensin II; autophagy; cardiac hypertrophy; oxidative stress; mTOR
摘要:Pathological cardiac hypertrophy is associated with nearly all forms of heart failure. It develops in response to disorders such as coronary artery disease, hypertension and myocardial infarction. Angiotensin II (Ang II) has direct effects on the myocardium and promotes hypertension. Chronic elevation of Ang II can lead to pathological cardiac hypertrophy and cardiac failure. Autophagy is an important process in the pathogenesis of cardiovascular diseases. Under physiological conditions, autophagy is an essential homeostatic mechanism to maintain the global cardiac structure function by ridding damaged cells or unwanted macromolecules and organelles. Dysregulation of autophagy may play an important role in Ang II-induced cardiac hypertrophy although conflicting reports on the effects of Ang II on autophagy and cardiac hypertrophy exist. Some studies showed that autophagy activation attenuated Ang II-induced cardiac dysfunction. Others suggested that inhibition of the Ang II induced autophagy should be protective. The discrepancies may be due to different model systems and different signaling pathway involved. Ang II-induced cardiac hypertrophy may be alleviated through regulation of autophagy. This review focuses on Ang II to highlight the molecular targets and pathways identified in the prevention and treatment of Ang II-induced pathological cardiac hypertrophy by regulating autophagy.
收录类别:SCOPUS;SCIE
WOS核心被引频次:10
Scopus被引频次:11
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85003811140&doi=10.1530%2fJME-16-0086&partnerID=40&md5=cb0201e116ac229e974102bb14b6a6ee
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