标题:Targeted Silencing of Inhibitors of Apoptosis Proteins with siRNAs: A Potential Anti-cancer Strategy for Hepatocellular Carcinoma
作者:Li, Gang; Chang, Hong; Zhai, Yun-Peng; Xu, Wei
作者机构:[Li, Gang; Chang, Hong; Zhai, Yun-Peng; Xu, Wei] Shandong Univ, Prov Hosp, Dept Gen Surg, Jinan 250100, Peoples R China.
通讯作者:Chang, H
通讯作者地址:[Chang, H]Shandong Univ, Prov Hosp, Dept Gen Surg, Jinan 250100, Peoples R China.
来源:ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
出版年:2013
卷:14
期:9
页码:4943-4952
DOI:10.7314/APJCP.2013.14.9.4943
关键词:Hepatocellular carcinoma; IAP; caspase; siRNA; therapy
摘要:Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a very poor prognosis. Despite significant improvements in diagnosis and treatment in recent years, the long-term therapeutic efficacy is poor, partially due to tumor metastasis, recurrence, and resistance to chemo- or radio-therapy. Recently, it was found that a major feature of tumors is a combination of unrestrained cell proliferation and impaired apoptosis. There are now 8 recognized members of the IAP-family: NAIP, c-IAP1, c-IAP2, XIAP, survivin, Bruce, Livin and ILP-2. These proteins all contribute to inhibition of apoptosis, and provide new potential avenues of cancer treatment. As a powerful tool to suppress gene expression in mammalian cells, RNAi species for inhibiting IAP genes can be directed against cancers. This review will provide a brief introduction to recent developments of the application IAP-siRNA in tumor studies, with the aim of inspiring future treatment of HCC.
收录类别:SCOPUS;SCIE
WOS核心被引频次:25
Scopus被引频次:27
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84887572318&doi=10.7314%2fAPJCP.2013.14.9.4943&partnerID=40&md5=3166ccd6cc686b99df47470565bc4690
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