标题：Targeted Silencing of Inhibitors of Apoptosis Proteins with siRNAs: A Potential Anti-cancer Strategy for Hepatocellular Carcinoma
作者：Li, Gang; Chang, Hong; Zhai, Yun-Peng; Xu, Wei
作者机构：[Li, Gang; Chang, Hong; Zhai, Yun-Peng; Xu, Wei] Shandong Univ, Prov Hosp, Dept Gen Surg, Jinan 250100, Peoples R China.
通讯作者地址：[Chang, H]Shandong Univ, Prov Hosp, Dept Gen Surg, Jinan 250100, Peoples R China.
来源：ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
关键词：Hepatocellular carcinoma; IAP; caspase; siRNA; therapy
摘要：Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a very poor prognosis. Despite significant improvements in diagnosis and treatment in recent years, the long-term therapeutic efficacy is poor, partially due to tumor metastasis, recurrence, and resistance to chemo- or radio-therapy. Recently, it was found that a major feature of tumors is a combination of unrestrained cell proliferation and impaired apoptosis. There are now 8 recognized members of the IAP-family: NAIP, c-IAP1, c-IAP2, XIAP, survivin, Bruce, Livin and ILP-2. These proteins all contribute to inhibition of apoptosis, and provide new potential avenues of cancer treatment. As a powerful tool to suppress gene expression in mammalian cells, RNAi species for inhibiting IAP genes can be directed against cancers. This review will provide a brief introduction to recent developments of the application IAP-siRNA in tumor studies, with the aim of inspiring future treatment of HCC.