标题：Utility of PET/CT in the Diagnosis and Staging of Extranodal Natural Killer/T-Cell Lymphoma A Systematic Review and Meta-Analysis
作者：Zhou, Xiangxiang; Lu, Kang; Geng, Lingyun; Li, Xinyu; Jiang, Yujie; Wang, Xin
作者机构：[Zhou, Xiangxiang; Lu, Kang; Geng, Lingyun; Li, Xinyu; Jiang, Yujie; Wang, Xin] Shandong Univ, Shandong Prov Hosp, Dept Hematol, Jinan 250021, Shandon 更多
通讯作者地址：[Wang, X]Shandong Univ, Shandong Prov Hosp, Dept Hematol, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
摘要：The role of F-18-fuorodexoyglucose-positron emission tomography/ computed tomography (F-18-FDG-PET/CT) in the staging of Hodgkin lymphoma (HL) and aggressive B-cell non-Hodgkin lymphomas (NHL) has been demonstrated extensively. Nevertheless, the role of PET/CT in the diagnosis, staging, prognosis, and treatment evaluation of natural killer (NK)/T-cell lymphoma remains indeterminate.; To systematically review and meta-analyze the publications on the value of F-18-FDG-PET/CT in the diagnosis and staging of NK/T-cell lymphoma.; Pubmed, Embase, Cochrane Library, and some other database were searched for initial studies (last updated on May 8th, 2014).; The eligibility criteria were studies assessing the usefulness of PET/CTin the staging ofNK/T-cell lymphoma, patientswere diagnosed asNK/T-cell lymphoma through pathology, or clinical and imaging follow-up.; Sensitivities and specificities of F-18-FDG-PET/CT in individual studies were assessed. The summary receiver operating characteristic curve (sROC) and the area under the curve (AUC) were calculated. The "Meta-Disc 1.4'' software was used for data analysis.; Eight studies, with a total of 135 NK/T-cell lymphoma patients, were included in this meta-analysis. In terms of the 6 studies with patient based data, the pooled sensitivity and specificity of PET/CT in the diagnosis of NK/T-cell lymphoma were 0.95 (95% CI: 0.89-0.98) and 0.40 (95% CI: 0.09-0.78), respectively. For lesion-based analysis, with 1546 lesions included, the pooled sensitivity and specificity of PET/CT in the staging of NK/T-cell lymphoma were 0.98 (95% CI: 0.96-0.99) and 0.99 (95% CI: 0.99-1.00), respectively. For the patient based data, the AUC and *Q index were 0.8537 and 0.7847, respectively. For lesion based data, the AUC and *Q index were 0.9959 and 0.9755, respectively.; The results of this current meta-analysis indicated that PET/CT could be used as a valuable diagnostic and staging tool for NK/T-cell lymphoma.