标题：Gingival extramedullary plasmacytoma converted to multiple myeloma: a case report and systematic review of the literature
作者：Li, Minghao; Yi, Cuihua; Zhang, Xiaofang; Qin, Xuemei; Sun, Limei; Wang, Aijun; Zhang, Wendong; Li, Jisheng
作者机构：[Li, Minghao] Shandong Univ, Sch Med, Jinan, Shandong, Peoples R China.; [Yi, Cuihua; Sun, Limei; Wang, Aijun; Zhang, Wendong; Li, Jisheng] Shandong 更多
通讯作者地址：[Li, JS]Shandong Univ, Qilu Hosp, Ctr Canc, Dept Med Oncol, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
来源：INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
关键词：Extramedullary plasmacytoma; multiple myeloma; gingiva; pleural effusion
摘要：Plasma cell tumors are lymphoid malignancies characterized by uncontrolled proliferation of B cells. Localized forms of this tumor are defined as extramedullary plasmacytoma and solitary bone plasmacytoma while multiple myeloma is defined as the disseminated type. A 70-year-old female presented with a swelling on the left cheek for more than 3 years. Physical examinations revealed a mass in intraoral gingiva on the left upper mandible. Computed tomography displayed pleural effusion, abnormal soft tissue density masses around spine and ribs, behind sternum and above adrenal glands as well as an osteolytic lesion in the body of several vertebrae. The biopsy in the gingival and post-sternal masses revealed plasmacytoma and bone marrow aspiration confirmed plasma cell infiltration (>10%). A diagnosis of multiple myeloma (StageI) converted from an initial gingival extramedullary plasmacytoma was established. The patient subsequently received 2 cycles of VAD regimen chemotherapy and the symptoms were temporarily relieved. We performed systematic reviews of literature and provided a meta-analysis of the frequency of extramedullary plasmacytoma progression to multiple myeloma. Both primary gingival extramedullary plasmacytoma and multiple myeloma with the first presentation in gingival are extremely rare, and yet for this case, we diagnosed as a primary gingival extramedullary plasmacytoma that had progressed to multiple myeloma.