标题：Role of Inflammasome in Chronic Kidney Disease
作者：Li, Liang; Tang, Wei; Yi, Fan
作者机构：[Li, Liang; Yi, Fan] Shandong Univ, Sch Basic Med Sci, Dept Pharmacol, Jinan 250012, Shandong, Peoples R China.; [Tang, Wei] Shandong Univ, Dept Pat 更多
通讯作者地址：[Yi, F]Shandong Univ, Sch Basic Med Sci, Dept Pharmacol, Jinan 250012, Shandong, Peoples R China.
来源：RENAL FIBROSIS: MECHANISMS AND THERAPIES
关键词：Inflammasome; Chronic kidney disease; Pattern recognition receptors;; Inflammation; Fibrosis
摘要：The inflammasome is a multiprotein complex assembled by intracytoplasmic pattern recognition receptors and is a key component of the innate immune system for host defense. Inflammasome recruits and activates the proinflammatory protease caspase-1 by recognizing pathogen-associated molecular patterns (PAMPs) or host-derived damage-associated molecular patterns (DAMPs). Activated caspase-1 cleaves the precursors of IL-1 beta and IL-18 to produce the corresponding mature cytokines. Several types of inflammasomes have been identified, such as NLRP3, NLRP1, IPAF (NLRC4) and AIM2. NLRP3 has recently been reported as a central pathogenic mechanism of chronic kidney disease (CKD). In this chapter, we briefly summarize the current knowledge about the roles of inflammasomes in the pathogenesis of CKD. A better understanding of the function of inflammasomes will provide unexpected opportunities to develop new therapies for kidney diseases by modulation of the innate immune system.