标题：Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications
作者：Guo, Junling; Mattos, Bruno D.; Tardy, Blaise L.; Moody, Vanessa M.; Xiao, Gao; Ejima, Hirotaka; Cui, Jiwei; Liang, Kang; Richardson, 更多 作者机构：[Guo, Junling; Cui, Jiwei] Shandong Univ, Minist Educ, Key Lab Colloid & Interface Chem, Jinan 250100, Shandong, Peoples R China.; [Guo, Junling; Xi 更多
通讯作者：Cui, JW;Liang, K;Richardson, JJ
通讯作者地址：[Cui, JW]Shandong Univ, Minist Educ, Key Lab Colloid & Interface Chem, Jinan 250100, Shandong, Peoples R China;[Liang, K]Univ New South Wales, Sch Che 更多
来源：CURRENT MEDICINAL CHEMISTRY
关键词：Nanomedicine; drug delivery; porous particles; hybrid; botanic delivery;; inorganic
摘要：Background: Porous micro- and nanoparticles have the capacity to encapsulate a large quantity of therapeutics, making them promising delivery vehicles for a variety of applications. This review aims to highlight the latest development of inorganic and hybrid (inorganic/organic) particles for drug delivery with an additional emphasis on combatting drug resistant cancer. We go one step further and discuss delivery applications beyond medicinal delivery, as there is generally a translation from medicinal delivery to botanic delivery after a short lag time.; Methods: We undertook a search of relevant peer-reviewed publications. The quality of the relevant papers was appraised using standard tools. The characteristics of the papers are described herein, and the relevant material and therapeutic properties are discussed.; Results: We discuss 4 classes of porous particles in terms of drug delivery and theranostics. We specifically focus on silica, calcium carbonate, metal-phenolic network, and metal-organic framework particles. Other relevant biomedically relevant applications are discussed and we highlight outstanding therapeutic results in the relevant literature.; Conclusion: The findings of this review confirm the importance of studying and utilizing porous particles for therapeutic delivery. Moreover, we show that the properties of porous particles that make them promising for medicinal drug delivery also make them promising candidates for agro-industrial applications.