标题:Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors
作者:Zhao, Wen Jing; Shi, Yong Heng; Zhao, Gui Long; Wang, Yu Li; Shao, Hua; Tang, Li Da; Wang, Jian Wu
作者机构:[Zhao Wenjing] School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.;[Wang Jianwu] School of Chemistry and 更多
通讯作者:Zhao, GL(zhao_guilong@126.com)
通讯作者地址:[Zhao, GL]Tianjin Inst Pharmaceut Res, Tianjin Key Lab Mol Design & Drug Discovery, Tianjin 300193, Peoples R China.
来源:中国化学快报
出版年:2011
卷:22
期:10
页码:1215-1218
DOI:10.1016/j.cclet.2011.05.022
关键词:Synthesis; C-Glucoside; SGLT2 inhibitor; Anti-hyperglycemic activity;; gem-Dimethyl
摘要:A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin. (C) 2011 Gui Long Zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
收录类别:CSCD;SCOPUS;SCIE
WOS核心被引频次:7
Scopus被引频次:7
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860410312&doi=10.1016%2fj.cclet.2011.05.022&partnerID=40&md5=56d6d65bf335daa062c9692b6f87b567
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