标题：Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring
作者：Chen, Da; Song, Shuren; Ma, Jilong; Zhang, Zhen; Wang, Peng; Liu, Weihui; Guo, Qiuquan
作者机构：[Chen, Da] Shandong Univ Sci & Technol, Educ Minist China, Mine Disaster Prevent & Control Key Lab, Qingdao 266590, Peoples R China.; [Chen, Da; Son 更多
通讯作者地址：[Chen, D]Shandong Univ Sci & Technol, Educ Minist China, Mine Disaster Prevent & Control Key Lab, Qingdao 266590, Peoples R China;[Guo, QQ]Univ Wester 更多
来源：BIOSENSORS & BIOELECTRONICS
关键词：Acoustic resonator; Film bulk acoustic resonator; Blood coagulation;; Micro-electromechanical system; Viscosity sensor
摘要：Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9 GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1 mu l. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R-2=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring.