标题:Regioselective synthesis of multisubstituted 1,2,3-triazoles: moving beyond the copper-catalyzed azide-alkyne cycloaddition
作者:Wei, Fang; Wang, Weiguo; Ma, Yudao; Tung, Chen-Ho; Xu, Zhenghu
作者机构:[Wei, Fang; Wang, Weiguo; Ma, Yudao; Tung, Chen-Ho; Xu, Zhenghu] Shandong Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Colloid & Interface Chem, 2 更多
通讯作者:Ma, YD;Xu, ZH;Xu, ZH
通讯作者地址:[Ma, YD; Xu, ZH]Shandong Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Colloid & Interface Chem, 27 South Shanda Rd, Jinan 250100, Shandong, People 更多
来源:CHEMICAL COMMUNICATIONS
出版年:2016
卷:52
期:99
页码:14188-14199
DOI:10.1039/c6cc06194j
摘要:Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an essential "click chemistry'' reaction that is widely used in chemical biology, medicinal chemistry and materials science. The CuAAC reaction of terminal alkynes provides a mild and efficient synthesis of 1,4-disubstituted 1,2,3-triazoles. However, the click reaction of internal alkynes with azides, giving trisubstituted triazoles, is very challenging. This feature article highlights the recent progress addressing this fundamental problem. Particular emphasis is on the current and emerging strategies to introduce functional groups to the C-5 position of triazoles in a regioselective manner.
收录类别:SCOPUS;SCIE
WOS核心被引频次:39
Scopus被引频次:42
资源类型:期刊论文
原文链接:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002604060&doi=10.1039%2fc6cc06194j&partnerID=40&md5=bcb931b34885e45c7094cd5400cf5167
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